Normalization, testing, and false discovery rate estimation for RNA-sequencing data
نویسندگان
چکیده
منابع مشابه
Normalization, testing, and false discovery rate estimation for RNA-sequencing data.
We discuss the identification of genes that are associated with an outcome in RNA sequencing and other sequence-based comparative genomic experiments. RNA-sequencing data take the form of counts, so models based on the Gaussian distribution are unsuitable. Moreover, normalization is challenging because different sequencing experiments may generate quite different total numbers of reads. To over...
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ژورنال
عنوان ژورنال: Biostatistics
سال: 2011
ISSN: 1465-4644,1468-4357
DOI: 10.1093/biostatistics/kxr031